Endocrine Abstracts

In 2005, Bergh et al. first described a cell surface receptor for thyroid hormones (TH) T3 and T4 on integrin αvβ3 that is expressed on tumour cells and dividing endothelial cells. The deaminated T4 derivative tetraiodothyroacetic acid (tetrac) is a specific inhibitor of integrin-mediated TH action. Building on Paul Davis’ pioneer studies, we are investigating the effects of TH and tetrac on mesenchymal stem cells (MSCs), important progenitor cells of t...